Overview: LSD's Subjective Effects Are Highly Reliant On 5-HT2A

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LSD administration elicited significant subjective effects, such as greater meaning/relevance scores when listening to normally meaningless music.

It was associated with increased activity in brain regions known to be connected to self-referential processing.

The drug's key effects were largely blocked by ketanserin, a 5-HT2A antagonist, indicating that receptor site is very important for LSD's activity in humans.

This paper points to receptor systems and brain regions that could be important in some psychiatric conditions that involve disrupted self-referential processing.

TDC paper overview page: https://thedrugclassroom.com/overview-lsds-subjective-effects-highly-reliant-5-ht2a/

Paper: http://www.cell.com/current-biology/abstract/S0960-9822(16)31510-X

Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/5sfyfw/overview_lsds_subjective_effects_are_highly/

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